What is Meridia?Over half of America is overweight and according to today’s society, ‘thin is in and fat is out’. The diet fads have taken over the nation, so the pharmaceutical industry stepped up to fill the place of 2 diet drugs that were withdrawn from the market in 1997. Meridia, a diet drug manufactured by by Knoll Pharmaceutical Co (also known as sibutramine hydrochloric monohydrate) is used to curb the appetite by using serotonin and norepinephrine. However, Meridia is now yet another diet drug taken off the market. How Does Meridia Work?Fenfluramine (the fen half of the trendy fen-phen drug mixture) and Redux (dexfenfluramine) were taken off the market in the Fall of 1997 after they were associated with causing fatal heart valve abnormalities. After of Fenfluramine and Redux were taken off the market, The Federal Drug Administration (FDA) approved Meridia in November 1997. A class of drug known as monoamine re-uptake inhibitors, Meridia is in the same class of anti-depressants, such as Prozac. The chemical, Serotonin, is released in the brain and is what makes a person feel full after eating a meal. When a nerve impulse arrives at the end of the nerve terminal, the neurotransmitters are released in the space amid the two adjacent neurons. That area is called the synaptic cleft. Typically when the neurotransmitters have attached to the receptors, the neurotransmitter and the receptor fit together like a key and lock onto the nearby nerve. Transport proteins help reabsorb the additional neurotransmitter back into the nerve terminal so that they can be reprocessed. On the other hand, Meridia gives the feeling that a person is full for a longer amount of time. The signal lasts longer because it slows down the reabsorption of serotonin, so it was thought that this process would ideally cut down the appetite of an overweight person. Meridia Side Effects Precaution needs to be used when taking Meridia even though it’s not as dangerous as other diet drugs. A few clinical trial participants – mainly those who had taken larger doses over 15 mg of Meridia - suffered side effects such as higher blood pressure, heart speed, and heart arrythmias. Using dose adjustments, the increases in blood pressure were controlled in these trials. Before taking the drug, the participants with high blood pressure were asked to consider the risks of taking Meridia. For all patients, the drug’s labeling suggestion requires pulse measurements and blood pressure before taking the drug and asks to monitor regularly afterwards. Side effects such as headache, dry mouth, insomnia and constipation are frequently reported, however can be easily tolerable. Need to contact a Meridia Diet Drug Lawyer?
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